A drug such as Remeron boosts the level of serotonin in the body, which causes weight gain. In a recent NHANES survey, antihistamine use was associated with obesity, and a study in the journal “Obesity,” (see abstract copied below) confirmed this and analyzed the use of over-the-counter antihistamines and their effect on weight gain. Send thanks to the doctor. Seriously, I've been taking Claritin for at least 15 years and I can't say I've had any side effects from it. An association between weight gain and receptor affinity was also observed in the models for 5HT2c, M3, and α1A receptors. It is very possible that the intake of antihistamines may cause weight gain. Atypical antidepressants are unique from other classes of antidepressants based on pharmacological properties. Antihistamines. Doctors believe that antihistamines promote weight gain … These days, the most common antidepressants fit into one of a few categories: SSRIs/SNRIs, TCAs, and MAOIs. Yes: After searching latest data upon seeing dr chiu's answer, I do agree old antihistamines do cause weight gain. In fact, one antihistamine in particular is actually used to promote weight gain. An antihistamine is used for treating common allergy symptoms, such as sneezing, watery eyes, hives, and a runny nose. Using an antihistamine may result in a few pounds gained here and there, but over the course of years – it can really start to add up. Yes: The older type of antihistamines do tend to lead to weight gain. Most seasonal allergy sufferers already know that common over-the-counter and prescription antihistamines can cause side effects such as drowsiness, dizziness, and dry mouth (to name a few). We found a significant association between the affinity of antidepressants to H1-receptor and weight gain (p value: <0.001). I've also managed to lose at least 50 pounds, while taking Claritin, so I personally wouldn't blame the medication for my weight … If I gain weight, it's because I eat too much and eat the wrong things. In a NHANES survey conducted in 2005 to 2006, antihistamine use was associated with excess weight, while a study from Yale University researchers confirmed this association and analyzed the use of over-the-counter antihistamines and their effect on weight gain. Another theory why antihistamines cause weight gain is that they increase appetite. Dr. John Chiu answered. The problem of weight gain and antihistamine use may become exacerbated by prolonged treatment. RELATED ARTICLE: Make Your Weight Loss Effortless with THIS Detoxing Drink. Some scientists theorize that antihistamines promote obesity since their structure is similar to the structure of psychiatric drugs that are associated with weight gain. When choosing an antihistamine—or trying to figure out where a new symptom came from—be aware that the medication can come with side effects, including some that may be a … The Little-Known Side Effect of OTC and Prescription Antihistamines Weight Gain. Antihistamines are the most common ways that prescription medication adds weight. Getty Images. Some of these antidepressants have antihistamine effects. The association between weight change and receptor affinities was estimated using meta-regression. Respectively these are: selective-serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), tricyclics (TCAs), and … “A lot of people gain weight without even realizing it, and if you don’t catch it until you’re six weeks in, that could mean you’re up 10 or more pounds.” ... Antihistamines. 4. 57 years experience Allergy and Immunology. 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